Clobetasole Propionate Ip/bp/ep/usp Cas No: 25122-46-7

Niksan Pharmaceutical is one of the leading Manufacturer, Exporter, Distributor, and Supplier of Clobetasol Propionate in Ankleshwar, Gujarat, India. To understand the largest accomplishment of clients, we present these products at very realistic price ranges. Niksan Pharmaceutical and Niksan group companies are nowadays one of the largest manufacturer and exporter of Clobetasol Propionate API and also finished formulations.

Niksan Pharmaceutical provides Clobetasol Propionate to all states of India like Punjab, Rajasthan, Andhra Pradesh, Haryana, Telangana, Bihar, Karnataka, Delhi, Tamil Nadu, Odisha, Maharashtra, West Bengal, Uttar Pradesh, Gujarat, and Madhya Pradesh etc. We also give gift samples to the companies for R&D purpose.

Niksan Pharmaceutical is one of leading manufacturer and exporterof Clobetasol Propionate for many years in all the countries like Puerto Rico, United States, Nepal, Philippines, Hong Kong, Nigeria, Bangladesh, United Arab Emirates, Pakistan, Taiwan, Singapore, Malaysia, Canada, Indonesia, Thailand, New Zealand, Vietnam, Israel, United Kingdome, Saudi Arabia, Chile, Australia, Colombia, France, Germany, Brazil and many other countries.
Clobetasol Propionate is class I corticosteroid medication. Clobetasol Propionate used in the treatment of many skin disease like skin rash, eczema, seborrheic dermatitis, psoriasis, contact dermatitis. Clobetasol Propionate is used in skin infections. Comes in many dosage forms like shampoo, cream, lotions, and ointment
SYNONYMS: Clobetasol 17-propanoate, Clobetasol 17-propionate, Clobetasol propionate, Clobetasol propionate E

IUPAC NAME:(1R,2S,10S,11S,13S,14R,15S,17S)-14-(2-chloroacetyl)-1-fluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracycloheptadeca-3,6-dien-14-yl propionate

CAS NO:25122-46-7

FORMULA:C25H32ClFO5

MOLECULAR MASS: 466.97 g/mol

STORAGE CONDITIONS: Store in cool and dry place, away from light and direct heat.Do not place medicine in bathroom or humid place.Keep away from children and pets.

HOW TO USE:Do not useClobetasol Propionate on face, under arms or on open wounds.Wash and clean the affected area and after that apply a thin film of Clobetasol Propionate gel on the area and gently rub it. Two time a day.

HOW CLOBETASOL PROPIONATE WORKS:Clobetasol Propionate binds with the glucocorticoid receptor and inhibits the pro-inflammatory receptor.Clobetasol Propionate promotes the anti-inflammatory signals to the brain and gives inflammatory effects.

PHARMACOKINETICS:Clobetasol Propionate absorbed systemic circulation after the application. Clobetasol Propionate takes 5 hours to reach the peak plasma concentration after using 2 times daily. The bioavaibility of Clobetasol Propionate is only 2.09%.The half-life of Clobetasol Propionate is 96hours.The medicine metabolises in liver and after it will excrete by biliary rout.

SIDE EFFECTS:Normally burning, skin irritation, stinging, dry skin, redness my seen at the site where medicine was applied.Contact your doctor I you see some side effects like stretch marks; skin tightening, acne, skin thinning, and unwanted hair grow.Some rare side effects like weakness, fainting, skin burning, rash, itching, weight loss, headache seen in patients.

PRECAUTIONS:Tell your doctor if you are allergic to the medication.
If you have medical history like weak immune system, skin problem, poor blood circulation problem, liver problem tell your doctor before using the medication.
The medication can temporarily slow down the childa s growth so take advice from doctor before giving to children.
Do not use this medication if you are in pregnancy or in lactation period.

CDSCO APPROVAL: Clobetasol propionate + Ammonium lactate gel is approved by CDSCO in India in 07.08.1996
Clobetasol propionate cream/ointment approved by CDSCO in India in October-1987
Clobetasol propionate bulk approved by CDSCO in India in October-1987
Nadifloxacin (1%) + Clobetasol (0.05%) approved by CDSCO in India in 06.10.2003

FORMULATIONS AVAILABLE IN MARKET:
Clobetasol propionate 0.05% w/w cream
Clobetasol propionate 0.05% w/v solution
Clobetasol propionate 0.025% w/w gel
Clobetasol propionate 0.05%w/w + Clotrimazole 1%w/w cream
Clobetasol propionate 0.05% w/w + Miconazole 2%w/w cream
Clobetasol propionate0.05% w/w + Luliconazole 1% w/w cream
Clobetasol propionate0.05% w/w + Terbinafine 1% w/w cream
Clobetasol propionate0.05% w/w + Nadifloxacin 1% w//w cream
Clobetasol propionate0.05% w/w + Salicylic acid 3% w/w cream
Clobetasol propionate0.05% w/w+ Fusidic acid 2% w/w cream
Clobetasol propionate 0.05% w/v+ Salicylic acid 3%w/v gel

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:


https://pubchem.ncbi.nlm.nih.gov


https://www.wikipedia.org/