Multi-color Monoclonal Antibody Murinization Service
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Product Overview
Key Features
We are the leading service provider involved in rendering services of Monoclonal Antibody Murinization Service. Creative Biolabs is proud to be the first company that offers professional Monoclonal Antibody Murinization Service. Relying on our unparalleled expertise in antibody engineering and affinity maturation, monoclonal antibodies with a variety of species background, such as human, rabbit, rat, chicken, bovine and dog can be successfully murinized without specificity switch and significant decrease in affinity.
Frequently, human therapeutic antibodies require a mouse counterpart so its efficacy can be tested in rodent animal models. In these cases, murinization of the human antibodies is the most straightforward method to achieve this goal. Based on our extensive experience in antibody humanization, we usually select the best matching murine antibody frameworks and then perform CDR grafting, which is then followed by construction and screening of a unique phage display library with designed mutation positions. In the end, multiple "murinized" mutants with the high-affinity retained can be obtained.
After murinization, the "murinized" frameworks greatly decrease their immunogenic in mice as compared to the parental antibody or chimeric murine-human antibody, and thus made them ideal antibodies for pharmacophore studies in rodents.
Frequently, human therapeutic antibodies require a mouse counterpart so its efficacy can be tested in rodent animal models. In these cases, murinization of the human antibodies is the most straightforward method to achieve this goal. Based on our extensive experience in antibody humanization, we usually select the best matching murine antibody frameworks and then perform CDR grafting, which is then followed by construction and screening of a unique phage display library with designed mutation positions. In the end, multiple "murinized" mutants with the high-affinity retained can be obtained.
After murinization, the "murinized" frameworks greatly decrease their immunogenic in mice as compared to the parental antibody or chimeric murine-human antibody, and thus made them ideal antibodies for pharmacophore studies in rodents.
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Company Details
Creative Biolabs, Established in 2004 at New York in New York, is a leading service provider of Others in United States. Creative Biolabs is one of Trade India's verified and trusted names for listed services. With extensive experience in the field of Others, Creative Biolabs has made a reputed name for itself in the market with satisfactory Anti-Hapten Antibody Production, Antibody Affinity Maturation, Antibody And Protein Purification Service, etc.
Focusing on a customer-centric approach, Creative Biolabs has a pan-India presence and caters to a huge consumer base throughout the country. Get Others from Creative Biolabs at Trade India quality-assured services.
Focusing on a customer-centric approach, Creative Biolabs has a pan-India presence and caters to a huge consumer base throughout the country. Get Others from Creative Biolabs at Trade India quality-assured services.
Business Type
Manufacturer, Service Provider, Supplier
Employee Count
1
Establishment
2004
Working Days
Monday To Sunday
Seller Details
New York, New York
Mr. Bella Smith
Address
SUITE 203, 17 Ramsey Road, Shirley, New York, New York, 11967, United States
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