Bispecific T Cell Engager (Bite)

We are the leading service provider involved in providing services of Bispecific T Cell Engager (BiTE). With the most advanced technology and years of experiences in antibody engineering field, Creative Biolabs now provide custom construction and production services for Bi-specific T-cell engagers (BiTEs). BiTE antibodies are recombinant fusion proteins consisting of two single-chain variable fragments (scFvs) of different antibodies. One of the scFvs binds to T cells via the CD3 receptor, and the other to a tumor cell via a tumor specific molecule. BiTEs are a very important class of artificial bi-specific monoclonal antibodies that are investigated for the use as anti-cancer drugs. By employing variable domains with binding specificities against different surface antigens of malignant cells and linking them to a CD3-binding domain, BiTEs can potentially be engineered to target a wide range of tumors.